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Millions of GWAS associations have been reported — but which genes are the true Predicted Effector Genes (PEGs)?

In April 2025, our Nature Genetics Perspective (with the GWAS Catalog) reviewed 169 publications (2012–2022, across 157 traits).

What did we learn?​

⚡ PEG prediction methods are highly inconsistent
⚡ Evidence types and reporting standards vary widely
⚡ The field urgently needs a common PEG standard

What’s next?​

At ASHG 2025, we’re bringing a new PEG standard designed to make PEG data FAIR — Findable, Accessible, Interoperable, and Reusable.

📍 Save the date in Boston

• 🗓️ Ancillary Session: Oct 17 | 11:45 am – 1:15 pm | Room 259A
• 📌 Poster: Oct 16 | 2:30 pm – 4:30 pm | Exhibit & Poster Hall, Lower Level

👉 Join us to shape the future of effector gene prediction and PEG standards: Sign up here

In September 2024, we hosted a workshop on Predicted Effector Gene (PEG) lists — key data for linking GWAS signals to biology.

Talks from the Knowledge Portal Network, Open Targets, GWAS Catalog, ClinGen, and others sparked ideas we are carrying forward.

We explored:

• 🔑 Different approaches to building PEG lists
• 🔑 Challenges in sharing, updating, and reusing them
• 🔑 First steps toward a community standard for reporting PEG data

👉 Missed it? Materials & recordings are available: Workshop Materials

Follow along as we count down to ASHG 2025, where we’ll share the outcomes through our poster and ancillary session.

📍 Save the date in Boston:

• 🗓️ Ancillary Session: Oct 17 | 11:45 am – 1:15 pm | Room 259A
• 📌 Poster: Oct 16 | 2:30 pm – 4:30 pm | Exhibit & Poster Hall, Lower Level

Join us to shape the future of effector gene prediction and PEG standards: Join Us